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no large-scale controlled human clinical trials establishing safety or efficacy currently exist

Epithalon structure and discovery Chemical composition: Tetrapeptide (four amino acids) Sequence: Ala-Glu-Asp-Gly (AEDG) Also called Epitalon or Epithalone Synthetic version of epithalamin (pineal gland extract) Molecular weight: 390.35 g/mol Water-soluble peptide Discovery history: Discovered by Professor Vladimir Khavinson in St

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It has been shown that the HBD family has a high affinity for LPS in vitro and can directly bind to LPS, thus inhibiting inflammatory response [139, 140]
[DOI] [PubMed] [Google Scholar] 62.Ye Z, Guo L, Barakat KJ, et al
