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Description
La glutathion-rductase permet ensuite la rduction rapide du glutathion oxyd pour complter le cycle : GSSG + NADPH + H + 2 GSH + NADP + Histoire [modifier | modifier le code] La glutathion-peroxydase a t dcouverte en 1957 par Gordon C

Glutathione metabolism was largely depicted by the glutamyl cycle proposed in 1970

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Guieu, R

Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition

While the cysteine decomposition is coupled with mitochondrial bioenergetics in the cells with intact KEAP1-NRF2 system, in NRF2-addicted cancer cells, most of the available cysteine appears to flow into the anabolic pathway, namely, glutathione synthesis and leaves the catabolic pathway in mitochondria, which is consistent with the observation that mitochondrial respiration is limited in NRF2-addicted cancer cells (Sayin et al
