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Patients with obesity might target a gradual weight loss of 10 to 20 kg over 6 months, as studies indicate this degree of weight loss can significantly improve ED [85,86]

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In conclusion, it is significant to clarify the driving role of these TGF- atypical pathways in CNI-ED, as relevant studies may reveal the complex cross-talk between these pathways and provide novel molecular targets for the selection of specific drugs

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