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Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control

Glucosylceramide synthase inhibitors have been shown to reduce the levels of glucosylceramide and glucosylsphingosine in the central nervous system, decelerate the accumulation of -syn, ubiquitin and tau proteins and improve cognitive and behavioral outcome in a GBA-associated PD mouse model (Sardi et al

Outcome monitoring should employ validated, condition-specific measures appropriate to the treatment indication

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Intranasal treatment with nanoparticles containing thyrotropin-releasing hormone significantly reduced the seizure afterdischarge duration and increased the number of stimulations required to reach a generalized tonicclonic seizure in a kindling model of temporal lobe epilepsy [250]