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In a 2009 study, Zama and Uzumcu (2009) employed bisulphitesequencing PCR and methylationspecific PCR to show that MTX produced hypermethylation in several CpGs in the ER promoter sequences

The breakdown of the 10mg total content depends on the specific manufacturing run

doi: 10.1126/scitranslmed.aav1648 174 ArbitmanLFurieRVashisthaH

Alm EM, Antonoff MB , Hess DJ, Acton RD, Saltzman DA

[DOI] [PubMed] [Google Scholar] 79.Guo A., Srinath J., Feuerecker M., Crucian B., Briegel J., Boulesteix A.L., Kaufmann I., Chouker A