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These cells, which express the mRNA for IGHV genes, but fail to express the surface protein, were cloned to obtain a homogeneous sIgM - population and edited to obtain clones with truncating mutations in exon 34 to delete the NOTCH1 PEST domain [21]

Epub 2012 Jan 28

Introduction Vitamin B12, or cobalamin, is a water-soluble vitamin, that plays an essential role in cellular metabolism, particularly in DNA synthesis, methylation processes, and mitochondrial functions (Green et al., 2017)

The liver is responsible for a variety of essential functions in the body, including the metabolism of fats, proteins, and carbohydrates