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As opposed to the loss of function of CFTR in CF, the enterotoxins of Vibrio cholerae (producing cholera) and certain Escherichia coli strains (travelers diarrhea) hyperactivate CFTR causing secretory diarrhea characterized by enhanced salt and water loss in feces [2, 5]

However, under pathological conditions, astrocytes can be a source of reactive oxygen species (ROS) or reactive nitrogen species (RNS) as a result of mitochondrial dysfunction, impaired metabolism, increased glutamate, and/or reduced antioxidant generation

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