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(See Kabat, et al

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When there is thiamine deficiency, the thiamine dependent enzyme alphaketoglutarate dehydrogenase (KGDH) will not be activated and will result in damage of the mitochondria and eventually cause cell death 4

Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism

Cell 153 (7), 14481460

Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study