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Pharmaceutics 18 , 787795 (2021)

Aizarani, N

Concurrently, an elevated ER/ER ratio, resulting from promoter methylation-induced ER upregulation and ER downregulation, amplifies estrogen signaling in endometriotic cells

Studies have shown that luteolin can inhibit calcium-activated chloride channels (CaCC) in Calu-3 cells, leading to reduced fluid hypersecretion, suggesting its therapeutic potential for conditions like asthma and COPD, which are characterized by excessive mucus production [234]

The decreased levels of GSH and increased oxidative stress trigger endothelial damage, decreasing endothelial NO, which activates NF- B, ultimately increasing production of prothrombotic adhesion molecules