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These technological approaches aid in elucidating the multipathway, multitarget mechanisms involved in thyroid diseases, providing a theoretical basis for the development of new natural medicines

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HLA-G in organ transplantation: towards clinical applications

In 2018, the Nomenclature Committee on Cell Death characterized ferroptosis as a type of regulated cell death caused by oxidative disruption within the intracellular microenvironment that is consistently regulated by GPX4 [20]

Accordingly, Keller and coworkers (63) demonstrated that once RNA is oxidized, protein synthesis significantly decreases over time in primary and the decrease is directly correlated with the oxidation time

While the kinetics and key residues involved in heme binding to GAPDH have been elucidated, its mechanism of interaction with target hemoproteins and transfer of heme remains unknown