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52,53 Wang et al revealed that the co-loading of tumor necrosis factor-related apoptosis-inducing ligand plasmid (pTRAIL) and gambogic acid (GA) significantly enhanced cytotoxicity against MCF-7 and MDA-MB-231 cells

In particular, modifications on the wobble uridine base (U 34 ), which base pairs with the third nucleotide of the mRNA codon, have been found to influence tRNA preference towards certain sequences and to aid in the reading of non-cognate codons (Zhou et al., 2021

Immunity 2019 , 51 , 491507

Mol Med (Camb, Mass)

doi: 10.1021/acs.jpcc.9b09520

The genetic possibility of errors cannot be totally excluded, but the consensus is in favor of an environmental problem affecting epigenesis and methylation [2,47,48,49,54,55,56]