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MT-2, on the other hand, affects a broader range of receptors, producing quicker and more intense tanning, while also having effects on appetite, metabolism, and sexual function

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The constrained conformation additionally positions the pharmacophore residues (His, D-Phe, Arg, Trp) in an optimal spatial arrangement for simultaneous contact with the MC receptor binding pocket, which is why cyclic melanocortin analogs consistently demonstrate 10-100 fold greater potency than their linear counterparts in cAMP accumulation assays

10.1007/s00535-010-0291-8 214