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As a brief introduction, binding of epidermal growth factor (EGF) to the extracellular domain of the EGF receptor (EGFR) leads to the assembly and activation of NADPH oxidase (Nox) that, in turn, generates endogenous H 2 O 2 [60]

Hepatocellular hypertrophy is typically identified by light microscopy and is associated with increased protein synthesis (assessed biochemically) and increased cytoplasmic organelles such as endoplasmic reticulum and peroxisomes (assessed by electron microscopy), or accumulation of intracellular components such as glycogen, lipid, or water

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Despite substantial success in treating liquid tumors, identifying appropriate tumor antigen targets (and overcoming exhaustion) for solid cancer-targeting CAR T cells remains challenging 115

However, the tumoral environment select populations with different dependences on mitochondria metabolism due to metabolic adaptation and plasticity

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