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2017 Jan 23;5(1):10

In fact, during oxidative stress conditions, there is an increase in the release of many factors, such as nuclear factor kappa (NFk), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2), leading to the enhancement of nitrosative stress and consequently the damage of fatty acids and proteins at the membrane level, all underpinning chronic fatigue [21]

Although the introduction of biodegradation provides opportunities to overcome airways defence and avoid the accumulation of polymeric materials, it has potential safety issues in other aspects

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It is noteworthy that in certain cases, vitamin C may reduce the body's immune response