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Abbreviations ALL: acute lymphoblastic leukemia CC: cancer cells CNS: central nervous system COX: cyclooxygenase DHA: docosahexaenoic acid EC: esophageal cancer EGCG: epigallocatechin gallate EPA: eicosapentaenoic acid IL: interleukin ITC: Isothiocyanate KD: ketogenic diet MUFA: monounsaturated fatty acids PUFA: polyunsaturated fatty acids SFA: saturated fatty acids TNF: tumor necrosis factor UGI: upper gastrointestinal Declarations Acknowledgement NPN would like to thank Mahidol University, Thailand, for providing Global Talent position

Lentiviral vector production, titration, and transduction For lentiviral vector production, 293 T cells were transfected with the packaging plasmid psPAX2, the viral envelope plasmid pMD2.G, and U7snRNA constructs using the Transporter 5 transfection reagent (Polysciences, Inc., Warrington, PA, USA, #26008) according to the manufacturers instructions