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As a consequence, both cycles sustain liver injury through continuous, irreversible chain reactions, with copper posing a greater risk due to its higher hepatic levels compared to iron [27]

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Pires M., Rego A.C

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In multiple cancer cell models, NRF2 silencing has been shown to reduce HIF-1 levels, resulting in the suppression of HIF-1-mediated cell proliferation, angiogenesis, tumor growth, and migration/invasion 45,51,52,53,54,55

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