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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

synthesized in all mammalian cells, most heavily in the liver Intracellular concentration: 0.2 to 10 mM in most cell types

Transporter dysfunction within the endolysosomal system leads to diverse systemic phenotypes

Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: model of diabetic retinopathy

The ability to drive safely becomes clearly impaired

10.1038/aja.2009.4 171