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Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines
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This interaction appears to initiate a series of intracellular signaling cascades
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Considering the difference between type of tissues and route of administration, this data suggests that mouse intraperitoneal model might not be a good predictor for evaluation of MAP attenuation in its natural host
however, severe oxidative stress results in shorter telomere lengths, and thus a delicate balance needs to be established in order to maximize the beneficial effects of free radicals and prevent the harmful effects caused by supraphysiological levels of such molecules
