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The ligand occupies the ATP binding site of c-Met, competes with ATP by forming hydrogen bonds with Met 1160, and binds with Asp 1222 in the active region of c-Met to form hydrogen bonds, thus producing strong kinase inhibitory activity (Fig

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Guthione injections have a positive effect on the whole body: they improve liver function and accelerate elimination

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Over-the-counter antiemetics like meclizine or dimenhydrinate may help for more persistent nausea, though sedation can be an issue

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