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Low levels may cause mood swings, irritability, or even a sense of persistent low spirits

Common adverse reactions include nausea, vomiting, diarrhea, and constipation, primarily due to delayed gastric emptying and hormonal effects on the digestive system

Following unilateral intrastriatal or medial forebrain bundle injection of 6-hydroxydopamine (6-OHDA)a classical neurotoxin used to mimic parkinsonian neurodegenerationthey observed pronounced leakage of FITC-labeled albumin and horseradish peroxidase into the ipsilateral striatum and substantia nigra at both 10 and 34 days post-lesion

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF

Staging vitamin B-12 (cobalamin) status in vegetarians

Crovesy, L., Ostrowski, M., Ferreira, D