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It is worth noting that HA exhibits favorable lubricating properties, particularly when cross-linked, as it forms a liquid matrix on the ocular surface

Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation

In biotin deficiency, metabolic disturbances and immune dysfunction can occur (62)

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Offline image processing used commercial and custom-written software for tissue segmentation, partial-volume analysis, and grid-shifting

Immunofluorescence for organoids The human and mouse intestinal organoids were first fixed with 4% paraformaldehyde and then permeabilized with 0.5% Triton X-100 (Beyotime, P0096)