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Late diagnosis and limited therapeutic effectiveness PD is often diagnosed only after substantial neurodegeneration has occurred where ~6080% of dopamine-producing neurons have been lost

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However, there are also a variety of non-motor symptoms that can occur, which can have a significant impact on the patients quality of life

Neurosci Lett, 535:104-109

The inability of antioxidant systems, such as GPX4 and FSP1, to detoxify LPOs lead to irreversible membrane damage and cell death
