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8 , 11 Alcohol and NSAIDs would also regularly induce various lesions in the other organs as well

doi:10.1002/mnfr.200700354

Horner, H

Archived from the original on 17 February 2017

The epoxide is then activated by the hydrogen bond with the tyrosine residues and opened by a nucleophilic attack of the aspartate (which is orientated and activated by a histidine residue, a second carboxylic acid amino acid, and potentially other amino acids located in the catalytic center) on one of the epoxide carbons forming an enzyme-substrate ester intermediate