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A multiyear trial looked at whether high-dose folic acid supplements could prevent new polyps in people who had a history of polyps

For VPA targets, the top 3 hub proteins based on degree were Prostaglandin-Endoperoxide Synthase 2 (PTGS2/COX2), Mammalian Target of Rapamycin (mTOR), and Toll Like Receptor 4 (TLR4), while the top 3 hub proteins based on BC score were PTGS2, mTOR, and Cannabinoid Receptor 1 (CNR1)

C-MC: Investigation, Methodology, Project administration, Supervision, Validation, Writing review & editing

Neurotrauma 37, 12211232

[DOI] [PubMed] [Google Scholar] 14.Warner GJ, Berry MJ, Moustafa ME, Carlson BA, Hatfield DL, Faust JR

18 mTORC1 integrates signals from nutrients and growth factors to regulate various anabolic processes, including protein synthesis, nucleotide production, lipid biosynthesis, and glycolysis, while inhibiting catabolic processes such as autophagy by phosphorylating ULK1/2 and sequestering lysosomal enzymes