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Unlike pharmaceutical agents (e.g., statins) that carry side effects (e.g., myopathy), probiotics are generally safe and exert pleiotropic effects, including cholesterol lowering, anti-inflammation, and endothelial protection ( 2 PRISMA compliance and literature selection process 3 Gut microbiota dysbiosis and atherosclerosis: the mechanistic link Gut microbiota dysbiosis contributes to AS through three interconnected pathways: metabolic dysregulation, inflammatory activation, and vascular dysfunction ( Figure 1 )

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doi:10.1016/j.atherosclerosis.2014.10.023 Rodriguez M, Ringstad L, Schafer P, et al

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