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Description
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: therapeutic implications

Male mice underwent rapid loss of survival at extended time points, while female mice were largely unaffected

In some people, especially those with reactive hypoglycemia or insulin resistance, these swings can be misread as thyroid symptoms

Clin Pharmacol Ther 2018;104:1155-64

Methods Mice To induce genetic ablation of the GHR, mice carrying loxP-flanked Ghr alleles 44 were bred either with AgRP-IRES-Cre mouse (Agrp tm1(cre)Lowl /J, The Jackson Laboratory), LepR-IRES-Cre mouse (B6.129-Lepr tm2(cre)Rck /J, The Jackson Laboratory) or Nestin-Cre mouse (B6.Cg-Tg (Nes-cre)1Kln /J, The Jackson Laboratory)
