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Funding This research project was funded by the South African Medical Research Council with funds from the National Treasury under its Economic Competitiveness and Support Package (MRC-RFA-UFSP-01-2013/VMH Study) and the South African National Research Foundation (Grant no

19 CYP2D6*36 has rare frequency in almost of all the populations except Asian population

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However, deficiency in either SMARCA4, SMARCB1 or PBRM1 attenuates recruitment of these transcription factors, thereby repressing expression of SLC7A11 , which then reduces transport of cystine into cells

Here, they are mainly involved in the defense against extracellular bacteria and fungi [14]

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