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2 Over one-third of women in the United States of childbearing age are obese and this number is steadily rising

Leaky gut is commonly recognized in functional medicine but remains controversial in conventional medicine, which acknowledges increased intestinal permeability in conditions like celiac or Crohns disease but may not classify it as a standalone diagnosis

To the best of our knowledge, this question has not yet been experimentally addressed

Hao et al., 2010

Cystine uptake assay Cystine uptake was measured as described previously 92

We next further investigated whether the observed bell-shaped profile induced by high concentrations of dimeric macrocycles (3,000 nM) or HGF (30 nM) might be due to off-target inhibition of constitutively activated RTKs, which could potentially transactivate Met phosphorylation