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In humans it is synthesized in the liver, kidney, and brain and actively transported to other areas of the body

Studies in older rats have shown that supplementation with high doses of acetyl-L-carnitine and alpha-lipoic acid (an antioxidant) can reduce mitochondrial decay

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The endpoint was a decrease of at least one NYHA class, with efficacy rated as effective (decrease of two classes, decrease of one class) or ineffective (no class change)

Dietary intake also plays an important role in carnitine homeostasis of HD patients since the prevalence of malnutrition ranges from 18% to 75% of these cases [54]

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