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In this paper, compounds were described that activate SOS-mediated nucleotide exchange and paradoxically inhibit downstream RAS signalling
However, the same environment carries the risk of oxidative damage, such as 8-oxo-7,8-dihydroguanine (8-oxoG) and single- or double-strand breaks, which activate base excision and other DNA repair pathways
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injection of RSL3 (10 mg kg 1 ) or vehicle for five consecutive days
Studies have shown that inhibition of p53 in tumor cell growth is related to increased ferroptosis sensitivity (22)
