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For some people, the benefits of these medications do not outweigh the risks, as with any other pharmacologic intervention (e.g., adults who have previously had medullary thyroid cancer, in which they are contraindicated)

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Structural peptides like BPC-157 carry minimal CNS interaction risk, while neuropeptides like Cerebrolysin and Dihexa modulate the same neurotransmitter systems that antidepressants target