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[70] Acne While n-acetylcysteine helps improve inflammatory lesions of acne by quenching reactive oxygen species, inhibition of leukotrienes and prostaglandins, stabilization of membranes and inhibiting lipid peroxidation, [71] its effect on comedones is less well defined and could be due to decreased sebum production or inhibition of Pityrosporum ovale , a potential comedogenic organism that has been demonstrated in comedones