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1) include 12 genetically distinct metabolic disorders, inherited as an autosomal recessive trait, with an estimated cumulative incidence from 1:6,500 to 1:110,000 [1]

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But you've reduced effective dose by nearly half through timing alone

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If you are well-versed in chemistry, this is a great representation of the anion gap: the anion gap = (Na + K) (C1 + CO2)

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