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Pope H.G., Kouri E.M., & Hudson J.I

Subsequent investigations demonstrated similar increases in creatine and phosphocreatine after 30 days of low-dose creatine administration (3 g/day) and after a loading dose (20 g/day for 6 days) and 2 g/day for 1 month [52,53,54]

This form of regulation is dependent on 5-reductase, an enzyme crucial for the production of the potent androgen, 5-dihydrotestosterone (DHT)

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