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In fact, the gene expression of NCs and CLCs showed substantial overlap, and Brachyury expression remained constant during IVD degeneration when NCs were replaced by CLCs [58, 76]

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Clinically, CMHs are detected using susceptibility-weighted MRI (SWI) and gradient-echo T2*-weighted imaging, which allow visualization of hemosiderin deposits indicative of chronic microvascular injury [6, 8,9,10,11,12,13,14]

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