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Their study demonstrated that stage 1 pancreatic cancers could be detected with high accuracy using a biomarker panel that included B7-1, IL-17E, DR6, and CA19-9, achieving an AUC of 0.988, with 100% sensitivity at 90% specificity

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This was not attributable to decreased S phase, because these cells had similar BrdU incorporation regardless of the treatment (Extended Data Fig

JAMA 333, 16741675

NNMT inhibition increases the levels of SAM and NAD + and upregulates the activation of polyamine flux, resulting in an increase in energy expenditure [11]