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The atherosclerotic plaques, especially the necrotic core of unstable plaques, contain apoptotic macrophages, erythrocytes and its metabolites - heme and hemoglobin (Li et al., 2006), and cytotoxic substances (cholesterol crystals, cholesterol esters, oxidized lipids, fibrin, inorganic minerals like hydroxyapatite, iron, and calcium) (Tong et al., 2023)

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Hence, the low levels of thiomethyl metabolites observed after APAP exposure are probably associated to the limited cytochrome P450 capabilities of in vitro models to generate NAPQI metabolites via CYP2E compared to in vivo hepatocytes

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