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The professional ROS producer, NADPH oxidase 4 (Nox4), has been shown to be upregulated in response to the TGF2 stimulation of rat lens epithelial explants, leading to EMT [162]
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The mechanistic and animal-model data for AOD9604 are relatively mature compared with many newer peptides, given the compound's formal drug-trial history
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Front Nutr 10:1136458
