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The oral bioavailability of SM is poor due to rapid metabolism, low intestinal permeability, and poor water solubility

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Thus, levels of certain metabolites are continuously monitored by a cell, directly informing cellular decisions on gene expression, affecting cellular differentiation as a result (Pavlova & Thompson, 2016)

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10 GCL is composed of two subunits: a heavy, catalytic subunit (GCLC) and a light, modifier subunit

The mitochondria-targeted lipophilic antioxidants MitoQ and MitoT protect against renal tubular injury and renal dysfunction by inhibiting mitochondrial damage and oxidative stress, as well as increasing mitochondrial NADPH levels [87]