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Research indicates retinol may also support mitochondrial function and counteract photo-oxidative stress in dermal fibroblasts through multiple signaling pathways including those related to cellular senescence

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One RAR will partner with a retinoid X receptor (RXR) and make a heterodimer.[17] RAR-gamma accounts for about 90 percent of RARs in the epidermis, and RXR-alpha accounts for roughly 90 percent of the RXRs

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Prior TW, Swoboda KJ, Scott HD, Hejmanowski AQ (2004) Homozygous SMN1 deletions in unaffected family members and modification of the phenotype by SMN2

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