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A B12 deficiency is often caused by diet or absorption problems

The guidelines state, However, pernicious anaemia in its true sense (that is, life-threatening anaemia) is now extremely rare because of developments in testing and treatment for, and greater awareness of, vitamin B 12 deficiency . In one sense, this statement is correct: the term pernicious anaemia, when taken literally, implies a severe, life-threatening form of anaemia, which is uncommon in modern practice due to improvements in testing and treatment, such severe manifestations are typically prevented, as the condition is more likely to be diagnosed earlier or treated with B 12

This review focuses on the analysis of the problem of vitamin B12 hypersensitivity and presents different protocols for cyanocobalamin desensitization based on available literature data

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Knocking out OSMR in sensory neurons or systemic administration of gp130 inhibitors suppresses inflammatory itch in mice (42)