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Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance

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According to studies published in the Journal of Cancer Science and Therapy, glutathione depletion causes increased oxidative stress, which can lead to cancer

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Moreover, metadherin, a positive regulator of EMT, can promote ferroptosis in many cancer cell lines by inhibiting the expression of GPX4 and SLC3A2 [112]