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doi:10.1016/j.ncrna.2023.11.008

This is consistent with observations that specific intratumoral BA profiles in CRC correlate with high Treg abundance and poor patient outcomes (75), and that BA dysregulation in hepatocellular carcinoma (HCC) is linked to Th17/Treg imbalances potentially affecting immunotherapy responses (76)

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Barrea L, Vetrani C, Caprio M, Cataldi M, Ghoch ME, Elce A, et al

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The condition develops slowly and worsens over time, eventually leading to the inability to carry out basic tasks such as eating, dressing, or communicating