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Proc Natl Acad Sci U S A 72:29942998 Nakahata N (2008) Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology

Our findings are the first to demonstrate that GCLC desuccinylation mediated by SIRT2 directly regulates the rapid activation of GCLC upon oxidative stress, which provides a promising adjunct therapeutic target for cancer treatment

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3,4 Importantly, interindividual responses may vary due to the oral nitrate-reducing microbiome, as antibiotics or antibacterial mouthwash can inhibit the conversion of nitrate to nitrite