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In a phase III study, known as COSMIC-312 (NCT03755791), which compared cabozantinib in combination with atezolizumab to sorafenib as a first-line therapy for advanced HCC, the combination therapy significantly improved PFS [142]

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A 2006 Phase I trial of CJC-1295 reported no serious adverse events across a small number of subjects, but it was a safety study, not an outcomes trial, and there are no large trials showing it does what enthusiasts hope

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