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Author contributions CB: Data curation, Writing original draft

Wu S-G, et al

However, glucagon effects are also exerted on hepatic lipid metabolism such that fatty acid synthesis is inhibited and fatty acid oxidation is enhanced

Glutathione deficiency alters the Vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice

The combined action of these events results in an increased local availability of free serum IGF-I, which is then transported by transcytosis using an endothelial transporter (lipoprotein related receptor 1) dependent mechanism[67]

Several glutathione-dependent enzymatic antioxidant pathways protect the cell from oxidant injury: glutathione peroxidase (GPx) uses GSH as a cofactor to reduce H2O2 and organic hydroperoxides, the overall reaction reducing peroxide molecules to water and oxidatively coupling two glutathiones to liberate GSSG (13)