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doi: 10.1080/14728222.2023.2240017

Finally, long-standing diabetes patients require an exogenous insulin injection to sustain high-insulin concentration, which is the so-called exogenous hyperinsulinemia. Moreover, a unique portal structure enables insulin secreted from the pancreatic islet to perfuse the exocrine pancreas first, significantly increasing the regional insulin concentration in PDA tissue

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Damian Holsinger, The University of Sydney, Australia Reviewed by Muhammad Usman Munir, Jouf University, Saudi Arabia Omamuyovwi Meashack Ijomone, University of Medical Sciences, Ondo, Nigeria Updates Copyright 2025 Yassin, Skrabulyte-Barbulescu, Alshamsi, Saeed, Alkuwaiti, Almazrouei, Alnuaimi, BaniYas, Aldhaheri, Alderei, Shehab and Hamad