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In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]
HIF-1 as a switch in mitochondria functioning In the hypoxic microenvironment of cancer cells, hypoxia-inducible factor-1 (HIF-1), mostly HIF-1, plays a pivotal role in mitochondrial abnormality as a transcriptional factor [174]
Some studies have proposed potential mechanisms
doi: 10.2147/CCID.S457958
