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Description
Symptoms of DPN vary according to the class of involved sensory fibers, presenting with pain and unpleasant sensations if small fibers are involved and with numbness and loss of protective sensation (LOPS) if large fibers are involved

One without the other is a recipe for ambiguity

The process may involve some trial and feedback with your provider

Health problems, like diabetes, can cause darkened skin too

Yu ZJ, Yan HL, Xu FH, Chao HC, Deng LH, Xu XD, et al

-20C, 1 month (protect from light) Publications (255) Journal Impact Factor Most Recent Signal Transduct Target Ther 2023 Feb 3;8(1):51
