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Numerous studies have revealed the complexity and diversity of the Nrf2-Keap1 pathway in regulating biological processes, including cell proliferation, differentiation, anti-inflammation, and cytoprotection (Murakami and Motohashi, 2015

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however, there exist distinct geographical differences in NAFLD prevalence, disease burden, and severity across various countries [4,5,12,13]

In contrast, the cis conformation of aberrantly phosphorylated tau (p-tau) has been linked to pathogenesis in neurodegenerative disease and of cognitive symptoms (65, 93, 94)